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Illustrated mitotic cells against a dark background
Pack 3 · Mitosis

The most beautiful thing in biology

The first time I saw a cell divide under a microscope, I forgot what my experiment was actually supposed to be about.

Seeing a cell, chromosomes lined up along an invisible equator, then two halves being pulled apart in opposite directions by the most beautiful web of microtubule spindles.

That moment triggered everything that came after - microscopy became my muse and I started drawing what I saw under the microscope like I had painted still lifes, chromosomes instead of apples, spindles instead of bowls. Eventually I left the bench and built a career in science communication, working on making biology readable to people who don't live inside it. All of it traces back to that one cell.

Mitosis is the process every cell in your body uses to make a copy of itself. It is also, I am willing to say out loud, the most beautiful thing in biology.

What does it actually look like?

You are a record of it

You started as one single cell.

To create life, egg and sperm fuse into a single cell carrying a complete set of DNA. That cell divides, then the two cells divide, then the four divide. By the time of birth, that single cell has become trillions of cells, all descended from the original through round after round of mitosis.

It is still happening. Right now, somewhere on your skin, a cell is in the middle of dividing. In your gut lining, your bone marrow, the inside of your mouth. Every minute of your life, somewhere in your body, a chromosome is being pulled into a new cell.

What it actually looks like

Before a cell can divide, it has to prepare. It doubles all of its DNA so there's a complete copy ready for each new cell, then tightens the strands into thick rods - chromosomes - so they don't tangle as they move.

The nuclear membrane breaks down. Fibers stretch from the two ends of the cell, reaching for the chromosomes and catching hold of them like fishing lines.

The chromosomes line up in a perfect row across the middle of the cell. This is the most beautiful moment. The line looks frozen, but each chromosome is held in tension between the two ends, both sides pulling at once like the start of a tug of war.

Then the tension breaks, the two halves of each chromosome heading for opposite ends at the same instant. The cell pinches in the middle and seals off, and where there was one, there are now two, each with a complete set of DNA.

This is happening billions of times a day inside you.

Eight stills

The eight cards in Pack 3 are eight stills from the sequence: the cell preparing, the chromosomes condensing, lining up, pulling apart, the two new cells forming. Each card is a frozen moment from one of the most coordinated processes in biology.

No one is in charge

There is no conductor inside the cell, no instructions being read out, no one deciding when to start. The fibers find the chromosomes on their own. The chromosomes line themselves up. The membrane pinches when the tension is right.

The cell organizes itself from the inside. Every plant, every animal, every fungus on earth divides this way, and has been since the first cell with a nucleus.

Still happening

The cells dividing in your body right now are running the same process that turned one fertilized cell into the person you are. Mitosis is how a body becomes a body, and how it stays one.

When you hold up the cards in Pack 3, you're showing your baby the choreography that built them, and that is still building them.